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claudin-2; SP82 (CLDN2)
Function:
- plays a major role in tight junction-specific obliteration of the intercellular space, through Ca+2-independent cell-adhesion activity (putative)
- can form homo- & heteropolymers with other CLDN homopolymers
- interacts with CLDN3, but not CLDN1, homopolymers
- directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3
Structure:
- belongs to the claudin family
Compartment:
- cell junction, tight junction
- cell membrane; multi-pass membrane protein
Pathology:
- defects may be associated with chronic pancreatitis [2]
Comparative biology:
- may serve as a novel biomarker for pre-diabetes in mice [3]
General
claudin
Properties
SIZE: entity length = 230 aa
MW = 25 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-7}
transmembrane domain {8-28}
exoplasmic loop {29-81}
transmembrane domain {82-102}
cytoplasmic loop {103-116}
transmembrane domain {117-137}
exoplasmic loop {138-162}
transmembrane domain {163-183}
cytoplasmic domain {184-230}
MOTIF: domain {229-230}
Database Correlations
OMIM 300520
UniProt P57739
Pfam PF00822
Entrez Gene 9075
Kegg hsa:9075
References
- UniProt :accession P57739
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Songtao Y, Fangyu L, Jie C, Li Y.
Identification of claudin-2 as a promising biomarker for early diagnosis of
pre-diabetes.
Front Pharmacol. 2024 Feb 15;15:1370708.
PMID: 38425650 PMCID: PMC10902111 Free PMC article.