clavulanate (clavulanic acid)

Clavulanic acid is produced by Streptomyces clavuligerus. It has poor intrinsic antimicrobial activity, but is a suicide inhibitor of beta-lactamases produced by a wide range of Gram+ & Gram- microorganisms. It is well absorbed by mouth, but can be given parenterally. It has been combined with amoxicillin as an oral preparation (Augmentin) & with ticarcillin in a parenteral preparation (Timentin).

General

beta-lactamase inhibitor carboxylate heterocyclic compound, 2 rings

Properties

INHIBITS: beta lactamase

Database Correlations

PUBCHEM correlations Kegg map/map00331

References

The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 1093

Component-of

amoxicillin/clavulanate (Augmentin) ticarcillin clavulanate (Timentin)