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CLARICOR trial

Multicenter, placebo-controlled study in Denmark 13,702 participants, age 18-85 with angina pectoris or myocardial infarction Protocol: - a single 14 day course of clarithromycin vs placebo - 3 year follow-up Primary outcome: - composite all cause mortality, myocardial infarction unstable angina Secondary outcome: - composite cardiovascular mortality, myocardial infarction, unstable angina Results: 1) no difference in primary outcome (Hazzard ratio 1.15) 2) increased cardiovascular mortality in patients with heart disease 1 year after 14 day course of clarithromycin (Hazzard ratio 1.27-1.45)

Related

clarithromycin (Biaxin)

General

clinical trial

References

  1. Prescriber's Letter 13(1): 2006 Clarithromycin mortality alert for patients with heart disease Detail-Document#: 220110 (subscription needed) http://www.prescribersletter.com
  2. Jespersen CM et al Randomised placebo controlled multicentre trial to assess short-term clarithromycin for patients with stable coronary heart disease. CLARICOR trial. BMJ 2006, 332:22 PMID: 16339220