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chronic kidney disease epidemiology (CKD-EPI) collaboration equation

Equation used to estimate GFR Principle: - complicated, ambiguous description [1] - uses minimum & maximum serum creatinine raised to [exp 1.209] - version that uses both minimum & maximum serum creatinine & minimum & maximum serum cystatin-C all raised to a different power - uses age - uses fudge factors for gender (female) & race (black) Notes: - superior to MDRD equation when GFR > 60 mL/min/1.73 m2 - superior to MDRD equation in elderly

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 17, 18. American College of Physicians, Philadelphia 2015, 2018
  2. Inker LA, Eckfeldt J, Levey AS et la Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values. Am J Kidney Dis. 2011 Oct;58(4):682-4. PMID: 21855190 Free PMC Article
  3. Levey AS, Fan L, Eckfeldt JH, Inker LA. Cystatin C for glomerular filtration rate estimation: coming of age. Clin Chem. 2014 Jul;60(7):916-9. PMID: 24871681 Free Article

Components

creatinine in serum/plasma