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cytoskeleton-associated protein 2 (tumor-associated microtubule- associated protein, CTCL tumor antigen se20-10, CKAP2, LB1, TMAP)
Function:
- possesses microtubule stabilizing properties
- role in regulating aneuploidy, cell cycling, & cell death (p53/TP53-dependent)
- associates with alpha-tubulin & beta-tubulin (putative)
Compartment:
- cytoplasm
- colocalizes with microtubules throughout the cell cycle
Alternative splicing: named isoforms=3
Expression:
- abundant in testis, thymus
- barely detectable in liver, prostate & kidney
Pathology:
- abundant in tumor derived cell lines
- up-regulated in primary human gastric cancers
General
microtubule-associated protein (MAP)
phosphoprotein
Properties
SIZE: MW = 77 kD
entity length = 683 aa
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S534}
Thr phosphorylation site {T579}
Thr phosphorylation site {T582}
Thr phosphorylation site {T597}
Ser phosphorylation site {S602}
Thr phosphorylation site {T623}
Database Correlations
UniProt Q8WWK9
References
UniProt :accession Q8WWK9