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creatine kinase BB

CK 1; 90% of total CK activity in brain.

General

creatine kinase

Properties

COMPARTMENT: inter mitochodrial membrane space MOTIF: kinase domain MOTIF: ATP-binding site NAME: ATP-binding site active site RESIDUES: cysteine residue SUBUNITS: creatine kinase B subunit (2) MOTIF: Tyr phosphorylation site {Y39} Tyr phosphorylation site {Y125} ATP-binding site NAME: ATP-binding site SITE: 128-132 Ser phosphorylation site {S164} ATP-binding site NAME: ATP-binding site SITE: 191-191 cysteine residue {C283} ATP-binding site NAME: ATP-binding site SITE: 292-292 ATP-binding site NAME: ATP-binding site SITE: 320-325 ATP-binding site NAME: ATP-binding site SITE: 335-335

References

  1. Teitz, Fundamentals of Clinical Chemistry, 3rd ed, WB Saunders, Philadelphia, pg 375
  2. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 273

Components

creatine kinase B subunit (CKB)