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keratin, type 1 cytoskeletal 10; cytokeratin-10; CK-10; keratin-10; K10 (KRT10 KPP)
Function:
- cytokeratin-10 is generally associated with cytokeratin-1
Structure:
- heterotetramer of 2 type 1 & 2 type 2 keratins
- belongs to the intermediate filament family
Expression:
- cytokeratin-1 & cytokeratin-10 are expressed in keratinizing squamous epithelium & squamous cell carcinomas
- seen in all suprabasal cell layers including stratum corneum
Polymorphism:
- number of alleles are known that mainly differ in the Gly-rich region (positions 490-560)
Pathology:
- defects in KRT10 are a cause of:
a) bullous congenital ichthyosiform erythroderma
b) ichthyosis annular epidermolytic
c) epidermal nevus epidermolytic hyperkeratotic type
General
cytokeratin, epithelial keratins or soft alpha-keratins
phosphoprotein
Properties
CONFIGURATION: oligomer
SIZE: entity length = 593 aa
MW = 60 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-145}
MOTIF: serine-rich region {6-144}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S16}
Ser phosphorylation site {S42}
Rod {146-456}
MOTIF: Coil 1A {146-181}
Linker 1 {182-202}
Coil 1B {203-294}
Linker 12 {295-317}
Coil 2 {318-456}
serine-rich region {451-590}
MOTIF: serine residue (SEVERAL)
Tail {457-593}
Database Correlations
OMIM correlations
MORBIDMAP 148080
UniProt P13645
Pfam PF00038
Entrez Gene 3858
Kegg hsa:3858
References
- Dabbs. Diagnostic Immunohistochemistry. Churchill Livingstone 2002.
page 167.
- Entrez Gene :accession 3858
- UniProt :accession P13645
- Human intermediate Filament mutation Database
http://www.interfil.org
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KRT10
- Wikipedia; Note: keratin-10 entry
http://en.wikipedia.org/wiki/keratin_10