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citron Rho-interacting kinase; CRIK; serine/threonine protein kinase 21 (CIT, KIAA0949, STK21)
Function:
- required for KIF14 localization to the central spindle & midbody
- may play a role in cytokinesis
- RHO/RAC effector that binds to the GTP-bound forms of RHO & RAC1
- probably binds p21 with a tighter specificity in vivo
- dual specificity protein kinase activity catalyzing autophosphorylation & phosphorylation of exogenous substrates on both Ser/Thr & Tyr
- role in regulation of cytokinesis & in development of the central nervous system (putative)
- directly interacts with KIF14 (stronger interaction with the kinase-inactive form)
- homodimer (putative)
- interacts with TTC3
Structure:
- belongs to the protein kinase superfamily, AGC Ser/Thr
- protein kinase family
- contains 1 AGC-kinase C-terminal domain
- contains 1 CNH domain
- contains 1 PH domain
- contains 1 phorbol-ester/DAG-type Zn+2 finger
- contains 1 protein kinase domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=3
General
serine/threonine kinase
zinc finger protein
Properties
SIZE: entity length = 2027 aa
MW = 231 kD
COMPARTMENT: cytoplasm
MOTIF: kinase domain
SITE: 97-360
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 103-111
ATP-binding site
NAME: ATP-binding site
SITE: 126-126
aspartate residue {D221}
AGC-kinase C-terminal {361-431}
Ser phosphorylation site {S433}
Ser phosphorylation site {S440}
coiled coil {453-1297}
MOTIF: Ser phosphorylation site {S480}
Rho/Rac interaction {1091-1302}
MOTIF: Tyr phosphorylation site {Y1196}
Zinc finger
NAME: Zinc finger
SITE: 1362-1411
EFFECTOR-BOUND: Zn+2
PH domain {1443-1563}
MOTIF: Tyr phosphorylation site {Y1478}
Ser phosphorylation site {S1582}
CNH {1591-1881}
SH3-binding site
NAME: SH3-binding site
SITE: 1953-1958
Ser phosphorylation site {S1971}
Ser phosphorylation site {S1993}
STATE: active state
Database Correlations
OMIM 605629
UniProt O14578
PFAM correlations
Entrez Gene 11113
Kegg hsa:11113
ENZYME 2.7.11.1
References
UniProt :accession O14578