circadian core oscillator

Function: - circadian rhythms Structure: - consists of: - CRY proteins - CLOCK or NPAS2 - BMAL1 or BMAL2 - CSNK1D &/or CSNK1E - TIMELESS - PER proteins

Properties

COMPARTMENT: cell nucleus SUBUNITS: tubulin-specific chaperone A MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl tubulin-specific chaperone B MOTIF: Tyr phosphorylation site {Y98} Tyr phosphorylation site {Y114} CAP/Gly domain {183-225} MOTIF: glycine residue (SEVERAL) tubulin-specific chaperone C tubulin-specific chaperone D MOTIF: HEAT repeat {361-399} HEAT repeat {557-594} HEAT repeat {596-632} tubulin-specific chaperone E MOTIF: CAP/Gly domain {27-71} MOTIF: glycine residue (SEVERAL) leucine-rich repeat SITE: 152-175 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 178-201 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 203-227 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 228-250 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 251-274 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 276-301 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 306-330 MOTIF: leucine residue (SEVERAL)

References

UniProt :accession Q15813

Components

tubulin-specific chaperone A (tubulin-folding cofactor A, CFA, TCP1-chaperonin cofactor A, TBCA) tubulin-specific chaperone B (tubulin-folding cofactor B, cytoskeleton-associated protein 1, cytoskeleton-associated protein CKAPI, TCP1-chaperonin cofactor B, TBCB, CKAP1, CG22) tubulin-specific chaperone C (tubulin-folding cofactor C, CFC, TCP1-chaperonin cofactor C, TBCC) tubulin-specific chaperone D (tubulin-folding cofactor D, tubulin-folding cofactor D, beta-tubulin cofactor D, tfcD, SSD-1, TBCD) tubulin-specific chaperone E (tubulin-folding cofactor E, TBCE)