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ciliary neurotrophic factor; CNTF (CNTF)
Function:
- CNTF is produced by Schwann cells in response to peripheral nerve injury & is transported anterogradely to the neuronal cell body
- CNTF lacks a classical peptide signal sequence for the secretory pathway & is probably released following cell disruption
Structure: belongs to the CNTF family
Compartment: cytoplasm
Expression:
- produced by Schwann cells
General
cytokine
secreted peptide without leader
Properties
SIZE: entity length = 200 aa
MW = 23 kD
COMPARTMENT: cytoplasm
SECRETED-BY: schwann cell
Database Correlations
OMIM 118945
UniProt P26441
Pfam PF01110
Entrez Gene 1270
Kegg hsa:1270
References
- Hopkins SJ & Rothwell NJ
Cytokines and the nervous system. I: Expression and recognition.
TINS 18:83 1995
PMID: 7537419
- UniProt :accession P26441
- Wikipedia; Note: ciliary neurotrophic factor entry
http://en.wikipedia.org/wiki/ciliary_neurotrophic_factor