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protein capicua homolog (CIC, KIAA0306)
Function:
- transcriptional repressor which may play a role in development of the central nervous system (CNS)
- interact with ATXN1 (putative)
Structure: contains 1 HMG box DNA-binding domain
Compartment: nucleus (putative)
Expression: expressed in fetal brain
Pathology: expressed in medulloblastoma
General
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 164 kD
entity length = 1608 aa
COMPARTMENT: cell nucleus
MOTIF: ATXN1 interaction {28-46}
proline-rich region
SITE: 42-138
MOTIF: proline residue (SEVERAL)
HMG box
SITE: 200-268
Ser phosphorylation site {S279}
proline-rich region
SITE: 508-1303
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S904}
Thr phosphorylation site {T1291}
Ser phosphorylation site {S1294}
Ser phosphorylation site {S1397}
Ser phosphorylation site {S1402}
Ser phosphorylation site {S1409}
Ser phosphorylation site {S1462}
proline-rich region
SITE: 1524-1601
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q96RK0
Pfam PF00505
References
UniProt :accession Q96RK0