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chymotrypsin-C; caldecrin (CTRC, CLCR)
Function:
- chymotrypsin-type protease activity & hypocalcemic activity
- preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa
Structure:
- belongs to the peptidase S1 family, elastase subfamily
- contains 1 peptidase S1 domain
Expression: pancreas
Pathology:
- genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective trypsin-degrading activity
General
chymotrypsin (alpha chymotrypsin)
Properties
SIZE: entity length = 268 aa
MW = 29 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
cysteine residue {C17}
MODIFICATION: cysteine residue {C141}
N-glycosylation site {N25}
S1 domain {30-267}
MOTIF: N-glycosylation site {N52}
cysteine residue {C59}
MODIFICATION: cysteine residue {C75}
histidine residue {H74}
cysteine residue {C75}
MODIFICATION: cysteine residue {C59}
aspartate residue {D121}
cysteine residue {C141}
MODIFICATION: cysteine residue {C17}
cysteine residue {C155}
MODIFICATION: cysteine residue {C222}
cysteine residue {C186}
MODIFICATION: cysteine residue {C202}
cysteine residue {C202}
MODIFICATION: cysteine residue {C186}
cysteine residue {C212}
MODIFICATION: cysteine residue {C243}
serine residue {S216}
cysteine residue {C222}
MODIFICATION: cysteine residue {C155}
N-glycosylation site {N226}
cysteine residue {C243}
MODIFICATION: cysteine residue {C212}
Database Correlations
OMIM 601405
MORBIDMAP 601405
UniProt Q99895
Pfam PF00089
Entrez Gene 11330
Kegg hsa:11330
ENZYME 3.4.21.2
References
UniProt :accession Q99895