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chylomicron remnant
Remnant particle remaining after chylomicron metabolism.
Characteristics:
- retains most of the cholesterol esters found in the chylomicron
- contains apolipoproteins:
a) apo B48
b) apo E
- size: 30-80 nm
- density: between that of VLDL & IDL
Pharmacokinetics:
- rapidly metabolized in liver after entering circulation, generally in < 10 min with catabolism mediated by the apo E receptor (LRP)-mediated endocytosis & lysosomal degradation
- estrogens stimulate chylomicron clearance
Related
apolipoprotein B48 (apoB48)
apolipoprotein E (APOE)
cholesterol ester
low-density lipoprotein (LDL) receptor related protein (LRP)
General
chylomicron
Figures/Diagrams
lipoprotein metabolism
References
- Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA &
Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1025