carbohydrate sulfotransferase 9; galNAc-4-O-sulfotransferase 2; galNAc-4-ST2; galNAc4ST-2; N-acetylgalactosamine-4-O-sulfotransferase 2 (CHST9)

Function: - catalyzes transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (galNAc) residues in both N-glycans & O-glycans - role in biosynthesis of glycoprotein hormones lutropin & thyrotropin, by mediating sulfation of their carbohydrate structures - higher activity toward carbonic anhydrase VI than toward lutropin - only active against terminal galNAcbeta1,galNAcbeta - isoform 2, but not isoform 1, is active toward chondroitin Structure: belongs to the sulfotransferase 2 family Compartment: - isoform 1: - Golgi membrane - single-pass type 2 membrane protein (putative) - isoform 2: secreted (probable) Alternative splicing: named isoforms=2 Expression: - highly expressed in trachea - also expressed in fetal lung, adult pancreas, testis & salivary gland - expressed at low level in pituitary gland, apex of the heart, adult lung, prostate & mammary gland - weakly or not expressed in heart, liver & spinal cord Note: - uncertain whether Met-1 or Met-8 is the initiator

Properties

SIZE: entity length = 443 aa MW = 52 kD COMPARTMENT: golgi MOTIF: transmembrane domain {13-33} N-glycosylation site {N159} N-glycosylation site {N243} N-glycosylation site {N324} N-glycosylation site {N437}

Database Correlations

OMIM 610191 UniProt Q7L1S5 Pfam PF03567 Entrez Gene 83539 Kegg hsa:83539

References

UniProt :accession Q7L1S5