carbohydrate sulfotransferase 10; HNK-1 sulfotransferase; HNK-1ST; HNK1ST; HuHNK-1ST (CHST10)

Function: - catalyzes transfer of sulfate to position 3 of terminal glucuronic acid of both protein- & lipid-linked oligosaccharides - role in biosynthesis of HNK-1 carbohydrate structure, involved in cell interactions during ontogenetic development & in synaptic plasticity in the adult - may be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis Structure: - belongs to the sulfotransferase 2 family Compartment: - Golgi membrane - single-pass type 2 membrane protein (putative) Expression: - in fetal tissues - predominantly expressed in brain, - weakly expressed in lung, kidney & liver - in adult tissues - expressed in brain, testis, ovary > heart, pancreas, skeletal muscle, spleen & thymus > other tissues - in brain, expressed at higher level in frontal lobe

Properties

SIZE: entity length = 356 aa MW = 42 kD COMPARTMENT: golgi MOTIF: transmembrane domain {7-27} N-glycosylation site {N99} N-glycosylation site {N228} N-glycosylation site {N316}

Database Correlations

OMIM 606376 UniProt O43529 Pfam PF03567 Entrez Gene 9486 Kegg hsa:9486

References

UniProt :accession O43529