chromosomal translocation t(X;18)(p11.2;q11.2) (synovial sarcoma)

- chromosomal translocation t(X;18)(p11.2;q11.2) involving SS18 may be a cause of synovial sarcoma a) the translocation is specifically found in more than 80% of synovial sarcomas b) the fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity c) heterogeneity in the position of the breakpoint can occur (low frequency)

Properties

GENERAL: chromosomal translocation FORM: t(X;18)(p11.2;q11.2) LOCUS: human X-chromosome P11.2 human chromosome-18 Q11.2 PATHOLOGY: acute leukemia SPLICED-GENES: protein SSXT protein SSX1 protein SSX2

References

UniProt :accession Q15532