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chromosomal translocation t(9;15)(q34;q14)
- chromosomal translocation t(9;15)(q34;q14) involving BRD3 with NUT is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
- t(9;15)(q34;q14 produces a BRD3-NUT fusion protein
Properties
GENERAL: chromosomal translocation
RELATED: NUT
bromodomain-containing protein 3
FORM: t(9;15)(q34;q14)
LOCUS: human chromosome-9 Q34
human chromosome-15 Q14
PATHOLOGY: acute myeloid leukemia (AML)
ABERRANT-GENE: bromodomain-containing protein 3
COMPARTMENT: cell nucleus
MOTIF: bromodomain {51-123}
Ser phosphorylation site {S259}
Ser phosphorylation site {S263}
Ser phosphorylation site {S281}
bromodomain {326-398}
coiled coil {453-524}
lysine-rich region {487-555}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S563}
coiled coil {645-684}
MOTIF: breakpoint {647-648}
serine-rich region {676-725}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S680}
Ser phosphorylation site {S682}
NUT
References
UniProt :accession Q15059