Contents

Search

chromosomal translocation t(8;21)(q22;q22) (AML-M2)

Translocation described as t8q22:21q22 resulting in over- expression of c-mos serine/threonine kinase. However c-mos maps to 8q11 (confusion regarding the c-mos locus in the past, see OMIM for c-mos). Found in acute myeloid leukemias particularly AML-M2, 18-40% of cases depending on reference []2].

Properties

GENERAL: chromosomal translocation FORM: t(8;21)(q22;q22) LOCUS: human chromosome-8 Q22 human chromosome-21 Q22 PATHOLOGY: AML-M2; acute myeloblastic leukemia with maturation ABERRANT-GENE: mos proto-oncogene

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 288
  2. Yergeau et al. Nature Genetics 15:303-6, 1997