chromosomal translocation t(8;10)(p21.3;q11.2) (thyroid papillary carcinoma)

- chromosomal translocation t(8;10)(p21.3;q11.2) involving PCM1 with RET is found in thyroid papillary carcinoma the translocation links the protein kinase domain of RET to the major portion of PCM1

Properties

GENERAL: chromosomal translocation FORM: t(8;10)(p21.3;q11.2) LOCUS: human chromosome-8 P21.3 human chromosome-10 Q11.2 PATHOLOGY: papillary thyroid carcinoma ABERRANT-GENE: pericentriolar material 1 protein COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S65} Ser phosphorylation site {S68} Ser phosphorylation site {S69} Ser phosphorylation site {S110} coiled coil {218-301} Ser phosphorylation site {S356} coiled coil {400-424} Ser phosphorylation site {S431} coiled coil {487-543} coiled coil {651-682} coiled coil {726-769} coiled coil {824-858} Ser phosphorylation site {S861} Ser phosphorylation site {S866} Ser phosphorylation site {S869} Ser phosphorylation site {S872} Thr phosphorylation site {T877} Ser phosphorylation site {S991} coiled coil {1062-1088} interaction with HAP1 {1278-1798} MOTIF: PCM1-JAK2 breakpoint {1313-1314} PCM1-JAK2 breakpoint {1368-1369} PCM1-JAK2 breakpoint {1469-1470} coiled coil {1514-1538} PCM1-RET breakpoint {1608-1609} Ser phosphorylation site {S1729} Ser phosphorylation site {S1764} Ser phosphorylation site {S1767} Ser phosphorylation site {S1775} interaction with BBS4 {1912-2023} MOTIF: PCM1-JAK2 breakpoint {1946-1947} c-ret protein COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-28} N-glycosylation site {N98} N-glycosylation site {N151} cadherin domain {168-272} MOTIF: N-glycosylation site {N199} N-glycosylation site {N336} N-glycosylation site {N343} N-glycosylation site {N361} N-glycosylation site {N367} N-glycosylation site {N377} N-glycosylation site {N394} N-glycosylation site {N448} N-glycosylation site {N468} N-glycosylation site {N554} transmembrane domain {636-657} breakpoint {712-713} kinase domain SITE: 724-1016 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 730-738 ATP-binding site NAME: ATP-binding site SITE: 758-758 Tyr phosphorylation site {Y806} Tyr phosphorylation site {Y809} aspartate residue {D874} Tyr phosphorylation site {Y900} Tyr phosphorylation site {Y905} Tyr phosphorylation site {Y981} Tyr phosphorylation site {Y1015} Tyr phosphorylation site {Y1062} Tyr phosphorylation site {Y1090} Tyr phosphorylation site {Y1096}

References

UniProt :accession Q9BZ95