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chromosomal translocation t(8;11) (gamma-heregulin)
- chromosomal translocation t(8;22) involving NRG1 with ODZ4 produces gamma-heregulin, a soluble activating ligand for the ERBB2 receptor-ERBB3 receptor complex that acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175)
- gamma-heregulin is not detected in breast carcinoma samples
Properties
GENERAL: chromosomal translocation
FORM: t(8;11)
LOCUS: human chromosome-8
COMPONENTS: centromere
chromosomal C-band
chromatid-fiber
telomere
human chromosome-11
COMPONENTS: centromere
chromosomal C-band
chromatid-fiber
telomere
PATHOLOGY: NIL
ABERRANT-GENE: neuregulin-1
COMPARTMENT: extracellular compartment
MOTIF: cysteine-rich region {58-91}
transmembrane domain {76-100}
threonine-rich region {211-232}
MOTIF: threonine residue (SEVERAL)
EGF domain {233-277}
MOTIF: cysteine residue {C237}
MODIFICATION: cysteine residue {C251}
cysteine residue {C245}
MODIFICATION: cysteine residue {C265}
cysteine residue {C251}
MODIFICATION: cysteine residue {C237}
cysteine residue {C265}
MODIFICATION: cysteine residue {C245}
cysteine residue {C267}
MODIFICATION: cysteine residue {C276}
cysteine residue {C276}
MODIFICATION: cysteine residue {C267}
teneurin-4
COMPARTMENT: plasma membrane
MOTIF: TENEURIN N-TERMINAL {23-340}
MOTIF: proline-rich region
SITE: 179-182
MOTIF: proline residue (SEVERAL)
transmembrane domain {346-366}
N-glycosylation site {N467}
EGF domain {562-831} (8)
MOTIF: cysteine residue {C566}
MODIFICATION: cysteine residue {C576}
cysteine residue {C570}
MODIFICATION: cysteine residue {C581}
cysteine residue {C576}
MODIFICATION: cysteine residue {C566}
cysteine residue {C581}
MODIFICATION: cysteine residue {C570}
cysteine residue {C583}
MODIFICATION: cysteine residue {C592}
cysteine residue {C592}
MODIFICATION: cysteine residue {C583}
NHL repeat domain {1216-1566}
MOTIF: N-glycosylation site {N1259}
N-glycosylation site {N940}
YD {1576-2380} (23)
N-glycosylation site {N2646}
References
UniProt :accession Q92794