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chromosomal translocation t(6;14)(p25;q32)
- chromosomal translocation t(6;14)(p25;q32) involving IRF4 with the IgH locus may be a cause of multiple myeloma
Properties
GENERAL: chromosomal translocation
RELATED: multiple myeloma
FORM: t(6;14)(p25;q32)
LOCUS: human chromosome-6 P25
human chromosome-14 Q32
PATHOLOGY: multiple myeloma
ABERRANT-GENE: interferon regulatory factor 4
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 23-125
immunoglobulin heavy chain
MOTIF: Ig heavy chain variable region
NAME: Ig heavy chain variable region
heavy chain constant region-1
MOTIF: cysteine residue {CH1.SITE1}
MODIFICATION: cysteine residue {CH1.SITE2}
cysteine residue {CH1.SITE2}
MODIFICATION: cysteine residue {CH1.SITE1}
cysteine residue {C-TO-CH1}
MODIFICATION: cysteine residue {C-TO-CL}
hinge region
MOTIF: cysteine residue {HINGE1}
MODIFICATION: cysteine residue {HINGE1}
cysteine residue {HINGE2}
MODIFICATION: cysteine residue {HINGE2}
heavy chain constant region-2
MOTIF: cysteine residue {CH2.SITE1}
MODIFICATION: cysteine residue {CH2.SITE2}
cysteine residue {CH2.SITE2}
MODIFICATION: cysteine residue {CH2.SITE1}
heavy chain constant region-3
MOTIF: cysteine residue {CH3.SITE1}
MODIFICATION: cysteine residue {CH3.SITE2}
cysteine residue {CH3.SITE2}
MODIFICATION: cysteine residue {CH3.SITE1}
References
UniProt :accession Q15306