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chromosomal translocation t(6;9)(p23;q34)
- chromosomal translocation t(6;9)(p23;q34) involving SET or DEK with NUP214/CAN is found in a subset of acute myeloid leukemia (AML); translocation results in formation of a DEK-CAN fusion gene
Properties
GENERAL: chromosomal translocation
FORM: t(6;9)(p23;q34)
LOCUS: human chromosome-6 P23
human chromosome-9 Q34
ABERRANT-GENE: set protein
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: Ser phosphorylation site {S7}
Ser phosphorylation site {S30}
acidic region {239-290}
MOTIF: acidic residue (SEVERAL)
Breakpoint {283-284}
protein DEK
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
acidic region {30-49}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S32}
Ser phosphorylation site {S51}
SAP {149-183}
nuclear translocation signal {205-221}
Ser phosphorylation site {S227}
acidic region {228-236}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S230}
Ser phosphorylation site {S231}
Ser phosphorylation site {S232}
acidic region {241-254}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S243}
Ser phosphorylation site {S244}
Ser phosphorylation site {S251}
Ser phosphorylation site {S276}
acidic region {300-310}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S301}
Ser phosphorylation site {S303}
Ser phosphorylation site {S306}
Ser phosphorylation site {S307}
DNA-binding motif
SITE: 337-351
DNA-binding motif
SITE: 367-371
CAN
References
UniProt :accession Q6DJT9