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chromosomal translocation t(5;8)(p13;q12)
Chromosomal translocation t(5;8)(p13;q12) involving PLAG1 with leukemia inhibitory factor receptor LIFR. This fusion occured in the 5'-non-coding sequences of both genes, exchanging regulatory control element while preserving the coding sequences.
Properties
GENERAL: chromosomal translocation
FORM: t(5;8)(p13;q12)
LOCUS: human chromosome-5 P13
human chromosome-8 Q12
ABERRANT-GENE: zinc finger protein PLAG1
COMPARTMENT: cell nucleus
MOTIF: KPNA2 interaction {2-84}
MOTIF: nuclear translocation signal {22-25}
Zn finger C2H2-type
SITE: 34-56
EFFECTOR-BOUND: Zn+2
zinc fingers {41-242}
MOTIF: Zn finger C2H2-type
SITE: 62-86
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 92-114
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 121-143
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 150-172
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 185-207
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 213-236
EFFECTOR-BOUND: Zn+2
transcriptional activation {243-500}
MOTIF: 3 sumoylation motifs {243-384}
Massive activation {385-500}
LIF binding protein
MOTIF: signal sequence {1-44}
fibronectin type III domain or F3 module {46-131}
MOTIF: cysteine residue {C55}
MODIFICATION: cysteine residue {C65}
N-glycosylation site {N64}
cysteine residue {C65}
MODIFICATION: cysteine residue {C55}
cysteine residue {C82}
MODIFICATION: cysteine residue {C90}
N-glycosylation site {N85}
cysteine residue {C90}
MODIFICATION: cysteine residue {C82}
N-glycosylation site {N131}
N-glycosylation site {N143}
N-glycosylation site {N191}
cysteine residue {C213}
MODIFICATION: cysteine residue {C270}
N-glycosylation site {N243}
cysteine residue {C270}
MODIFICATION: cysteine residue {C213}
N-glycosylation site {N303}
fibronectin type III domain or F3 module {332-428}
MOTIF: cysteine residue {C341}
MODIFICATION: cysteine residue {C351}
cysteine residue {C351}
MODIFICATION: cysteine residue {C341}
N-glycosylation site {N390}
N-glycosylation site {N407}
N-glycosylation site {N426}
fibronectin type III domain or F3 module {433-530}
MOTIF: N-glycosylation site {N445}
cysteine residue {C466}
MODIFICATION: cysteine residue {C511}
N-glycosylation site {N481}
N-glycosylation site {N489}
cysteine residue {C511}
MODIFICATION: cysteine residue {C466}
WSXWS motif {519-523}
fibronectin type III domain or F3 module {535-625}
MOTIF: N-glycosylation site {N572}
fibronectin type III domain or F3 module {627-719}
MOTIF: N-glycosylation site {N652}
N-glycosylation site {N663}
N-glycosylation site {N680}
fibronectin type III domain or F3 module {724-829}
MOTIF: N-glycosylation site {N729}
N-glycosylation site {N787}
transmembrane domain {834-858}
box1 motif
SITE: 869-877
FOR-BINDING-OF: Janus kinase (JAK)
Ser phosphorylation site {S927}
References
UniProt :accession Q6DJT9