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chromosomal translocation t4p16.3:14q32.3 (multiple myeloma, FGFR3)

- chromosomal translocation t(4;14)(p16.3;q32.3) involving FGFR3 with the IgH locus may be a cause of multiple myeloma - increased expression & activating mutations in FGFR3

Properties

GENERAL: chromosomal translocation RELATED: immunoglobulin heavy chain multiple myeloma FORM: t(4;14)(p16.3;q32.3) LOCUS: human chromosome-4 P16.3 human chromosome-14 Q32.3 PATHOLOGY: multiple myeloma ABERRANT-GENE:

References

  1. UniProt :accession O96028
  2. Chesi M et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nature Genetics 16:260-4, 1997 PMID: 9207791