chromosomal translocation t3q26:21q22 (AML1, Evi1)

- chromosomal translocation t(3;21)(q26;q22) involving EVI1 with RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML) & therapy-related myelodysplastic syndrome

Properties

GENERAL: chromosomal translocation RELATED: evi-1 proto-oncogene AML1 or CBFA2 gene FORM: t3q26:21q22 (AML1, Evi1) PATHOLOGY: acute myeloid leukemia (AML) SPLICED-GENES: AML1 or CBFA2 gene evi-1 proto-oncogene

References

Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 519