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chromosomal translocation t(2;5)(p23;q35.1)

- chromosomal translocation t(2;5)(p23;q35.1) involving CD246 (ALK) with NPM1 is found in a form of non-Hodgkins lymphoma - the resulting chimeric NPM1-ALK protein homodimerizes & the kinase becomes constitutively activated Epidemiology: - accounts for 5-10% of non-Hodgkin lymphomas

Properties

GENERAL: chromosomal translocation FORM: t(2;5)(p23;q35.1) LOCUS: human chromosome-2 P23 human chromosome-5 Q35.1 PATHOLOGY: non-Hodgkin's lymphoma

References

  1. UniProt :accession Q9UM73
  2. UniProt :accession P06748