chromosomal translocation t(1;14)(p22;q32) (MALT lymphoma)

- chromosomal translocation t(1;14)(p22;q32) involving BCL10 with IgH is recurrent in low-grade MALT lymphoma; although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations may occur via the Ig somatic hypermutation mechanism resulting in nucleotide transitions

Properties

GENERAL: chromosomal translocation RELATED: MALT lymphoma FORM: t(1;14)(p22;q32) MALT lymphoma LOCUS: human chromosome-1 Q22 human chromosome-14 Q32 PATHOLOGY: MALT lymphoma SPLICED-GENES: B-cell lymphoma/leukemia 10 immunoglobulin heavy chain

References

UniProt :accession O95999