chromosomal translocation t(1;22)(p13;q13) (acute megakaryoblastic leukemia)

Pathology: - chromosomal translocation t(1;22)(p13;q13) involving MKL1 with RBM15 may be a cause of acute megakaryoblastic leukemia - both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7) - the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene & is the candidate oncoprotein

Properties

GENERAL: chromosomal translocation RELATED: AML-M7; acute megakaryoblastic leukemia FORM: t(1;22)(p13;q13) LOCUS: human chromosome-1 P13 human chromosome-22 Q13 PATHOLOGY: myelodysplastic syndrome SPLICED-GENES: MKL/myocardin-like protein 1 RNA-binding protein 15