chromosomal translocation t(16;21)(p11;q22)

Translocation associated with acute myeloid leukemia, involving genes for erg & fus.

Properties

GENERAL: chromosomal translocation FORM: t(16;21)(p11;q22) LOCUS: human chromosome-16 P11 human chromosome-21 Q22 PATHOLOGY: acute myeloid leukemia (AML) ABERRANT-GENE: erg proto-oncogene FUS/TLS gene

References

Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 519