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chromosomal translocation t(12;16)(q13;p11.2)
- chromosomal translocation t(12;16)(q13;p11.2) involving FUS with ATF1 is associated with angiomatoid fibrous histiocytoma; translocation generates a chimeric FUS/ATF1 protein
Properties
GENERAL: chromosomal translocation
RELATED: activating transcription factor-1
FUS/TLS gene
FORM: t(12;16)(q13;p11.2)
LOCUS: human chromosome-12 Q13
human chromosome-16 P11.2
PATHOLOGY: myxoid liposarcoma
ABERRANT-GENE: FUS/TLS gene
activating transcription factor-1
COMPARTMENT: cell nucleus
MOTIF: KID {31-90}
MOTIF: Ser phosphorylation site {S63}
DNA-binding motif
SITE: 215-235
leucine zipper
SITE: 241-262
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 612160
References
- OMIM :accession 612160