chromosomal translocation t(11;22)(q24;q12) (Ewing's sarcoma)

- chromosomal translocation t(11;22)(q24;q12) involving FLI1 with EWSR1 is a cause of Ewing sarcoma; translocation results in fusion protein FLI1-EWS

Properties

GENERAL: chromosomal translocation RELATED: Friend leukemia virus integration-1 (fli1) or Sic1 gene EWS gene Ewing's sarcoma FORM: t(11;22)(q24;q12) LOCUS: human chromosome-11 Q24 human chromosome-22 Q12 PATHOLOGY: Ewing's sarcoma ABERRANT-GENE: Friend leukemia virus integration-1 (fli1) or Sic1 gene EWS gene

References

Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 402