chromosomal translocation t(11;19)(q23;p13.3)

- chromosomal translocation t(11;19)(q23;p13.3) involving MLLT1 with MLL/HRX is associated with acute leukemias; the result is a rogue activator protein

Properties

GENERAL: chromosomal translocation FORM: t(11;19)(q23;p13.3) LOCUS: human chromosome-11 Q23 human chromosome-19 P13.3 ABERRANT-GENE: protein ENL COMPARTMENT: cell nucleus MOTIF: YEATS {8-112} Ser phosphorylation site {S155} Ser phosphorylation site {S209} proline-rich region SITE: 272-280 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S292} Ser phosphorylation site {S296} Ser phosphorylation site {S315} serine-rich region {319-325} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S359} Ser phosphorylation site {S361} Ser phosphorylation site {S366} serine-rich region {374-389} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 457-460 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 463-466 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S475} histone-lysine N-methyltransferase 2A COMPARTMENT: cell nucleus MOTIF: serine-rich region {17-102} MOTIF: serine residue (SEVERAL) glycine-rich region {137-143} Ser phosphorylation site {S153} A+T hook SITE: 169-180 Ser phosphorylation site {S197} A+T hook SITE: 217-227 A+T hook SITE: 301-309 Ser phosphorylation site {S518} proline-rich region SITE: 561-564 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 568-571 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S680} Thr phosphorylation site {T840} Ser phosphorylation site {S926} Ser phosphorylation site {S1056} Zinc finger NAME: Zinc finger SITE: 1147-1195 EFFECTOR-BOUND: Zn+2 breakpoint {1334-1335} breakpoint {1362-1363} MOTIF: breakpoint {1362-1363} breakpoint {1362} breakpoint {1406-1407} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1431-1482 EFFECTOR-BOUND: Zn+2 MOTIF: breakpoint {1444-1445} breakpoint {1444-1445} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1479-1533 EFFECTOR-BOUND: Zn+2 Zn finger PHD-type NAME: Zn finger PHD-type SITE: 1566-1627 EFFECTOR-BOUND: Zn+2 Bromo; divergent {1703-1748} Thr phosphorylation site {T1845} Ser phosphorylation site {S1858} FYR N-terminal {2018-2074} Ser phosphorylation site {S2098} Thr phosphorylation site {T2147} Ser phosphorylation site {S2151} Ser phosphorylation site {S2201} Thr phosphorylation site {T2525} proteolytic site {2666-2667} proteolytic site {2718-2719} 9aaTAD {2847-2855} Ser phosphorylation site {S2955} Ser phosphorylation site {S3036} Thr phosphorylation site {T3372} Ser phosphorylation site {S3511} Ser phosphorylation site {S3515} FYR C-terminal {3666-3747} arginine residue {3765} SET domain {3829-3945} MOTIF: binding site SITE: 3839-3839 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 3841-3841 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 3883-3883 FOR-BINDING-OF: S-adenosylmethionine S-adenosyl-L-methionine binding {3906-3907} Zn+2-binding site SITE: 3909-3909 post-SET domain {3953-3969} MOTIF: Zn+2-binding site SITE: 3957-3957 binding site SITE: 3958-3958 FOR-BINDING-OF: S-adenosylmethionine Zn+2-binding site SITE: 3959-3959 Zn+2-binding site SITE: 3964-3964