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chromosomal translocation t11q23:15q14 (AML)

* chromosomal translocation t(11;15)(q23;q14) involving ZFYVE19 with MLL/HRX is associated with acute myeloblastic leukemia AML) * chromosomal translocation t(11;15)(q23;q14) involving CASC5 with MLL/HRX is associated with acute myeloblastic leukemia (AML) translocation may give rise to a MLL-CASC5 fusion protein

Properties

GENERAL: chromosomal translocation RELATED: MLL gene zinc finger FYVE domain-containing protein 19 acute myeloid leukemia (AML) FORM: t11q23:15q14 LOCUS: human chromosome-11 Q23 human chromosome-15 Q14 PATHOLOGY: acute myeloid leukemia (AML) ABERRANT-GENE: MLL gene

References

  1. UniProt :accession Q96K21
  2. UniProt :accession Q8NG31 - Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/Genes/AF15q14ID318.html