chromosomal translocation t10q26:19q13.3 (glioblastoma)

chromosomal translocation t(10;19)(q26;q13.3) involving ZNF320 with BRWD2/WDR11 is found in a form of glioblastoma

Properties

GENERAL: chromosomal translocation RELATED: glioblastoma multiforme FORM: t(10;19)(q26;q13.3) LOCUS: human chromosome-10 Q26 human chromosome-19 Q13.3 PATHOLOGY: acute leukemia ABERRANT-GENE: zinc finger protein 320 COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 8-80 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 161-183 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 189-211 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 217-239 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 245-267 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 273-295 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 301-323 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 329-351 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 357-379 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 385-407 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 413-435 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 441-463 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 469-491 EFFECTOR-BOUND: Zn+2 WD repeat-containing protein 11 COMPARTMENT: cellular membrane MOTIF: WD repeat {59-108} WD repeat {111-154} WD repeat {354-393} Ser phosphorylation site {S402} Ser phosphorylation site {S406} WD repeat {471-510} WD repeat {566-605} WD repeat {708-745} WD repeat {747-787} WD repeat {793-831} WD repeat {893-940} Tyr phosphorylation site {Y1086} transmembrane domain {1127-1147}

References

UniProt :accession Q8WYB5