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chromosomal translocation t(10;14)(q24;q32) (B-cell non Hodgkin lymphoma)
- chromosomal translocation t(10;14)(q24;q32) involving NFKB2 with IGHA1 is found in a case of B-cell non Hodgkin lymphoma, the resulting oncogene is also called Lyt-10C alpha variant
Properties
GENERAL: chromosomal translocation
RELATED: non-Hodgkin's lymphoma
FORM: t10q24:14q32
LOCUS: human chromosome-10 Q24
human chromosome-14 Q32
PATHOLOGY: non-Hodgkin's lymphoma
ABERRANT-GENE: NF-kappa B p52 subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RHD {38-343}
MOTIF: nuclear translocation signal {337-341}
GRR {346-377}
glycine-rich region {350-400}
Cleavage {454-455}
ankyrin repeat
NAME: ankyrin repeat
SITE: 487-519
MOTIF: Breakpoint {490-491}
ankyrin repeat
NAME: ankyrin repeat
SITE: 526-555
ankyrin repeat
NAME: ankyrin repeat
SITE: 559-591
ankyrin repeat
NAME: ankyrin repeat
SITE: 599-628
ankyrin repeat
NAME: ankyrin repeat
SITE: 633-663
ankyrin repeat
NAME: ankyrin repeat
SITE: 667-696
Ser phosphorylation site {S713}
Ser phosphorylation site {S715}
Ser phosphorylation site {S717}
ankyrin repeat
NAME: ankyrin repeat
SITE: 729-758
death domain
NAME: death domain
SITE: 764-851
Ser phosphorylation site {S866}
Ser phosphorylation site {S870}
immunoglobulin alpha-1 chain (Ig-alpha 1)
MOTIF: Ig heavy chain variable region
NAME: Ig heavy chain variable region
heavy chain constant region-1
MOTIF: cysteine residue {CH1.SITE1}
MODIFICATION: cysteine residue {CH1.SITE2}
cysteine residue {CH1.SITE2}
MODIFICATION: cysteine residue {CH1.SITE1}
cysteine residue {C-TO-CH1}
MODIFICATION: cysteine residue {C-TO-CL}
hinge region
MOTIF: cysteine residue {HINGE1}
MODIFICATION: cysteine residue {HINGE1}
cysteine residue {HINGE2}
MODIFICATION: cysteine residue {HINGE2}
heavy chain constant region-2
MOTIF: cysteine residue {CH2.SITE1}
MODIFICATION: cysteine residue {CH2.SITE2}
cysteine residue {CH2.SITE2}
MODIFICATION: cysteine residue {CH2.SITE1}
heavy chain constant region-3
MOTIF: cysteine residue {CH3.SITE1}
MODIFICATION: cysteine residue {CH3.SITE2}
cysteine residue {CH3.SITE2}
MODIFICATION: cysteine residue {CH3.SITE1}
References
UniProt :accession Q00653