chromosomal translocation t10q22:11q23 (acute leukemia)

chromosomal translocation t(10;11)(q22;q23) of CXXC6 with MLL (5' MLL-CXXC6 3') is associated with acute leukemia (rare)

Properties

GENERAL: chromosomal translocation RELATED: histone-lysine N-methyltransferase 2A CXXC-type zinc finger protein 6 acute leukemia FORM: t(10;11)(q22;q23) LOCUS: human chromosome-10 Q22 human chromosome-11 Q23 PATHOLOGY: acute leukemia ABERRANT-GENE: CXXC-type zinc finger protein 6 COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 584-625 EFFECTOR-BOUND: Zn+2 coiled coil {2062-2091} MLL gene

References

UniProt :accession Q8WYB5