chromosomal inversion inv(16)(p13.1;q22.1)

- inversion inv(16)(p13q22) involving CBFB with MYH11 is associated with AML-M4 - inversion results in a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2-beta) with the tail region of MYH11 - the PEPB2-MYH11 fusion protein interacts with HDAC8 & RUNX1

Properties

GENERAL: chromosomal inversion FORM: inv(16)(p13.1;q22.1) LOCUS: human chromosome-16 P13 human chromosome-16 Q22 SPLICED-GENES: core-binding factor [CBF]-beta myosin heavy chain 11 HDAC8 RUNX1

References

UniProt :accession Q9BY41