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chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2 (CHD2)
Function:
- sequence-selective DNA-binding protein (putative)
ATP + H2O = ADP + phosphate
Structure:
- belongs to the SNF2/RAD54 helicase family
- contains 2 chromo domains
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
General
chromodomain-helicase-DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 1828 aa
MW = 211 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {13-74}
MOTIF: serine residue (SEVERAL)
serine-rich region {121-139}
MOTIF: serine residue (SEVERAL)
Thr phosphorylation site {T240}
Ser phosphorylation site {S242}
chromodomain
NAME: chromodomain
SITE: 261-353
FOR-BINDING-OF: heterochromatin
chromodomain
NAME: chromodomain
SITE: 378-456
FOR-BINDING-OF: heterochromatin
helicase
NAME: helicase
SITE: 496-666
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 509-516
DEAD/H box
NAME: DEAD/H box
SITE: 617-620
Ser phosphorylation site {S747}
Helicase C-terminal {795-946}
glutamate-rich region {966-1066}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S1012}
Ser phosphorylation site {S1801}
Ser phosphorylation site {S1807}
Database Correlations
OMIM 602119
UniProt O14647
PFAM correlations
Entrez Gene 1106
Kegg hsa:1106
ENZYME 3.6.4.12
References
UniProt :accession O14647