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nicotinic receptor beta-4; neuronal acetylcholine receptor subunit beta-4 (CHRNB4)
Function:
- nicotinic receptor beta
- may be component of function nicotinic receptor composed of nicotinic receptor alpha & nicotinic receptor beta subunits
- CHRNB4 can be combined CHRNA2, CHRNA3, or CHRNA4 to give rise to functional receptors
- interaction with RIC3 is required for proper folding & assembly
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment: cell junction, synapse, postsynaptic cell membrane
General
nicotinic receptor beta subunit
Properties
SIZE: entity length = 498 aa
MW = 56 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {21-236}
MOTIF: signal sequence {1-21}
N-glycosylation site {N36}
N-glycosylation site {N93}
N-glycosylation site {N138}
cysteine residue {C153}
MODIFICATION: cysteine residue {C167}
N-glycosylation site {N166}
cysteine residue {C167}
MODIFICATION: cysteine residue {C153}
transmembrane domain {237-257}
cytoplasmic loop {258-265}
transmembrane domain {266-286}
exoplasmic loop {287-298}
transmembrane domain {299-319}
cytoplasmic loop {320-460}
transmembrane domain {461-481}
exoplasmic domain {482-498}
Database Correlations
OMIM 118509
UniProt P30926
PFAM correlations
Entrez Gene 1143
Kegg hsa:1143
References
UniProt :accession P30926