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nicotinic receptor alpha-5; neuronal acetylcholine receptor subunit alpha-5 (CHRNA5, NACHRA5)
Function:
- neuronal nicotinic receptor alpha subunit
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment:
- cell junction, synapse, postsynaptic cell membrane
Pathology:
- genetic variations in CHRNA5 may be associated with susceptibility to lung cancer type 2
General
nicotinic receptor alpha
Properties
SIZE: entity length = 468 aa
MW = 53 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-254}
MOTIF: signal sequence {1-22}
N-glycosylation site {N155}
cysteine residue {C170}
MODIFICATION: cysteine residue {C184}
N-glycosylation site {N183}
cysteine residue {C184}
MODIFICATION: cysteine residue {C170}
N-glycosylation site {N229}
cysteine residue {C234}
MODIFICATION: cysteine residue {C235}
cysteine residue {C235}
MODIFICATION: cysteine residue {C234}
transmembrane domain {255-275}
cytoplasmic loop {276-281}
transmembrane domain {282-302}
exoplasmic loop {303-316}
transmembrane domain {317-337}
cytoplasmic loop {338-429}
transmembrane domain {430-451}
exoplasmic domain {452-468}
Database Correlations
OMIM correlations
MORBIDMAP 118505
UniProt P30532
PFAM correlations
Entrez Gene 1138
Kegg hsa:1138
References
UniProt :accession P30532