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nicotinic receptor alpha-3; neuronal acetylcholine receptor subunit alpha-3 (CHRNA3, NACHRA3)
Function:
- nicotinic receptor alpha
- forms neuronal nicotinic receptors with CHRNB2, CHRNB3 & CHRNB4
- interaction with RIC3 is required for proper folding & assembly
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment: cell junction, synapse, postsynaptic cell membrane
Alternative splicing: named isoforms=2
Pathology:
- genetic variations in CHRNA3 may be associated with
a) susceptibility to lung cancer type 2
b) peripheral arterial occlusive disease type 2
General
nicotinic receptor alpha
Properties
SIZE: entity length = 503 aa
MW = 57 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-238}
MOTIF: signal sequence {1-29}
N-glycosylation site {N53}
cysteine residue {C157}
MODIFICATION: cysteine residue {C171}
N-glycosylation site {N170}
cysteine residue {C171}
MODIFICATION: cysteine residue {C157}
cysteine residue {C221}
MODIFICATION: cysteine residue {C222}
cysteine residue {C222}
MODIFICATION: cysteine residue {C221}
transmembrane domain {239-263}
cytoplasmic loop {264-270}
transmembrane domain {271-289}
exoplasmic loop {290-304}
transmembrane domain {305-326}
cytoplasmic loop {327-475}
transmembrane domain {476-495}
exoplasmic domain {496-503}
Database Correlations
OMIM correlations
MORBIDMAP 118503
UniProt P32297
PFAM correlations
Entrez Gene 1136
Kegg hsa:1136
References
UniProt :accession P32297