muscarinic M2 receptor; muscarinic acetylcholine receptor M2 (CHRM2)

Function: - muscarinic acetylcholine receptor - primary transducing effect is inhibition of adenylate cyclase (via Gi protein) - in the CNS, CHRM2 is a presynaptic autoreceptor which down-regulates release of acetylcholine from presynaptic terminals Structure: belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane, cell junction, synapse - presynaptic cell membrane Polymorphism: - genetic variations in CHRM2 can influence susceptibility to alcoholism - genetic variations in CHRM2 can influence susceptibility to major depressive disorder

General

muscarinic receptor phosphoprotein

Properties

SIZE: entity length = 466 aa MW = 52 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-22} MOTIF: N-glycosylation site {N2} N-glycosylation site {N3} N-glycosylation site {N6} N-glycosylation site {N9} transmembrane domain {23-45} cytoplasmic domain {46-59} transmembrane domain {60-80} exoplasmic domain {81-97} MOTIF: cysteine residue {C96} MODIFICATION: cysteine residue {C176} transmembrane domain {98-119} cytoplasmic domain {120-139} transmembrane domain {140-162} exoplasmic domain {163-184} MOTIF: cysteine residue {C176} MODIFICATION: cysteine residue {C96} transmembrane domain {185-207} cytoplasmic domain {208-388} transmembrane domain {389-409} exoplasmic domain {410-423} transmembrane domain {424-443} cytoplasmic domain {444-466} MOTIF: Thr phosphorylation site {T446} Thr phosphorylation site {T450} Thr phosphorylation site {T465} MISC-INFO: Ki [PIRENZEPINE] HIGH INHIBITOR = AFDX116 INHIBITOR = METHOCTRAMINE INHIBITOR = HIMBACINE INHIBITOR = TRIPITRAMINE

Database Correlations

OMIM correlations UniProt P08172 Pfam PF00001 Entrez Gene 1129 Kegg hsa:1129