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cholinephosphotransferase 1 (diacylglycerol cholinephosphotransferase 1, hCPT1, AAPT1-like protein, CHPT1, CPT1, MST022)
Function:
- catalyzes phosphatidylcholine biosynthesis from CDP-choline
- role in the formation & maintenance of vesicular membranes
CDP-choline + 1,2-diacylglycerol CMP + phosphatidylcholine
Cofactor: Mg+2 or Mn+2
Structure:
- belongs to the CDP-alcohol phosphatidyltransferase class-I family
Compartment: Golgi membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in testis, colon, small intestine, heart, prostate, spleen > kidney, skeletal muscle, pancreas, leukocytes, ovary, thymus > brain, placenta, lung
Pathology:
- overexpressed in cancerous breast epithelial cell lines
General
phosphotransferase
transmembrane 8 protein
Properties
SIZE: MW = 45 kD
entity length = 406 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {66-86}
transmembrane domain {93-113}
transmembrane domain {153-173}
transmembrane domain {193-213}
transmembrane domain {226-248}
transmembrane domain {261-281}
transmembrane domain {295-315}
transmembrane domain {349-369}
Database Correlations
UniProt Q8WUD6
Pfam PF01066
ENZYME 2.7.8.2
References
UniProt :accession Q8WUD6