calcineurin B homologous protein 2; hepatocellular carcinoma-associated antigen 520 (CHP2, HCA520)

Function: - binds to & activates SLC9A1/NHE1, thus increasing pH - protects cells from serum deprivation-induced death - binds to SLC9A1/NHE1 Structure: contains 4 EF-hand domains Expression: - not detected in normal tissues Pathology: - expressed in malignantly transformed cells

Related

aberrantly expressed proteins/genes in cancer calcineurin-B or phosphatase-3 (2B) regulatory subunit

General

Ca+2 binding protein myristoylated protein

Properties

SIZE: entity length = 196 aa MW = 22 kD COMPARTMENT: cellular membrane MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate EF hand SITE: 26-61 EF hand SITE: 71-106 EF hand SITE: 111-146 MOTIF: Ca+2-binding site SITE: 124-135 EF hand SITE: 152-187 MOTIF: Ca+2-binding site SITE: 165-176

Database Correlations

UniProt O43745 Pfam PF00036 Entrez Gene 63928 Kegg hsa:63928

References

UniProt :accession O43745