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choriocarcinoma
Pathology:
1) germ cell neoplasm & gestational trophoblastic tumor
2) highly malignant tumor with high propensity to hemorrhage
3) microscopic pathology:
- sheets of trophoblastic cells without chorionic villi that invade surrouding tissues and vascular spaces
- cellular mixture of syncytiotrophoblast, cytotrophoblast & intermediate trophoblast
- central hemorrhage and necrosis common
- strong immunoreactivity for HCG
4) metastases:
- lung 80%
- vagina 30%
- pelvis 20%
- brain 10%
- liver 10%
Genetics:
- implicated genes MGAT4A
Interactions
disease interactions
Specific
primary intracranial choriocarcinoma
General
carcinoma
germ cell neoplasm
gestational trophoblastic disease (trophoblastic neoplasm)
References
- Pallais JC, McInnis M, Saylor PJ, Wu RI.
Case 38-2015.
N Engl J Med. 2015 Dec 10;373(24):2358-2369.
A 21-Year-Old Man with Fatigue and Weight Loss
PMID: 26650156
- Gestational Trophoblastic Tumors (PDQ): Treatment
http://www.cancer.gov/cancertopics/pdq/treatment/gestationaltrophoblastic/HealthProfessional