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chorea
Etiology:
1) Sydenham chorea with rheumatic fever
2) Huntington's chorea
3) neuroacanthocytosis
4) choreoathetosis
5) drug-induced chorea
6) vascular chorea
7) autoimmune chorea
- systemic lupus erythematosus
- antiphospholipid syndrome [4]
8) chorea gravidarum [2]
9) hyperglycemia [2]
Clinical manifestations:
- irregular, spasmodic, involuntary movements* of the limbs & muscles of the face, often accompanied with hypotonia (from the french choros: a dance)
* involuntary movements are not suppressible
Laboratory:
- pregnancy test (female of child-bearing age)
- serum glucose
- also see
- systemic lupus erythematosus
- antiphospholipid syndrome
- Huntington's chorea
Management:
- also see Huntington's chorea
- tetrabenazine up to 100 mg/day or amantadine 300-400 mg/day or riluzole 200 mg/day [2]
- deutetrabenazine (Austedo) FDA-approved April 2017
- valbenazine
Related
athetosis
Huntington's disease; Huntington's chorea (progressive hereditary chorea)
Specific
chorea gravidarum
choreoathetosis
Sydenham chorea (Saint Vitus dance)
General
movement disorder
involuntary movement
References
- Stedman's Medical Dictionary 26th ed, Williams &
Wilkins, Baltimore, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 19.
American College of Physicians, Philadelphia 2012, 2015, 2021.
- Walker RH
Differential diagnosis of chorea.
Curr Neurol Neurosci Rep. 2011 Aug;11(4):385-95
PMID: 21465146
- Hu S, Zhou Y, Li M, Zeng X, Zhao J.
Dancing with disorder: chorea - an unusual and neglected manifestation of
antiphospholipid syndrome.
Lupus Sci Med. 2024 Oct 1;11(2):e001332.
PMID: 39353714 PMCID: PMC11448224 Free PMC article.
https://lupus.bmj.com/content/11/2/e001332
- NINDS Chorea Information Page
https://www.ninds.nih.gov/Disorders/All-Disorders/Chorea-Information-Page