chordoid glioma of the third ventricle

Epidemiology: - rare slow growing tumor of the third ventricle (no reports of other sites) - adults (age range 30 - 70 years, mean 46 years) - 3:1 female predominance Microscopic Pathology: - clusters & cords of epitheliod GFAP + cells - variabley mucinous stroma with lymphoplasmacytic infiltrate - mitoses absent or rare - little tendency for microscopic infiltration of surrounding brain - reactive astrocytes, Rosenthal fibers, chronic inflammation in adjacent non-neoplastic tissues Immunohistochemistry: - GFAP + - vimentin + - S100 variably - EMA focal - EGFR + - schwannomin + - MIB-1 labelling low Differential diagnosis: - pituitary adenoma - craniopharyngioma - pilocytic astrocytoma - meningioma (chordoid) Notes: provisional WHO grade II

References

WHO Classification Tumours of the Nervous System. Kleihues & Cavenee eds. IARC Press 2000