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chondrosarcoma
malignant neoplasm of cartilage, may be skeletal or extraskeletal.
Epidemiology:
- adults
Pathology:
1) histologically similar to chondrosarcoma
2) immunohisotchemistry:
- vimentin: +
- S100: +
- NSE: +
- CD57: +
- keratin: -
- EMA: -
- CEA: -
- desmin: -
Genetics:
- chromosomal translocation t(9;17)(q22;q11) involving TAF2N with NR4A3 is found in a form of extraskeletal myxoid chondrosarcoma
- other implicated genes CSAG1, CSAG2, EXT1
Clinical manifestations:
1) pain
2) tends to present in axial skeleton in middle-age adults
Radiology:
1) X-ray of affected region
a) lucencies developing within calcification
b) periostal reactions
c) soft tissue mass
2) CT, MRI or bone scan useful
Management:
- surgical resection
Interactions
disease interactions
General
chondroid neoplasm (cartilage neoplasm)
sarcoma
Database Correlations
OMIM 215300
References
- Gajewski DA et al,
Differentiating clinical and radiographic features of
enchondroma and secondary chondrosarcoma in the foot.
Foot Ankle Int. 2006, 27:240
PMID: 16624212
- Weiner SD,
Enchondroma and chondrosarcoma of bone: clinical, radiologic
and histologic differentiation.
Instr Course Lect 2004, 53:645
PMID: 15116654
- Flemming DJ and Murphey MD,
Endochondroma and chondrosarcoma.
Semin Musculoskelet Radiol 2000, 4:59
PMID: 11061692
- PubMed Search
PubMed search: chondrosarcoma