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chondroitin sulfate

Biochemistry: - chondroitin sulfate constitutes the predominant proteoglycan present in cartilage & is distributed on the surfaces of many cells & extracellular matrix - carbohydrate sulfotransferase 3 (CHST3) sulfates chondroitin to form chondroitin-6-sulfate - major excreted mucopolysaccharide in normal individuals is chondroitin-6-sulfate - chondroitin-4-sulfate is found is association with inter-alpha-trypsin inhibitor - carbohydrate sulfotransferases (CHST11, CHST12, CHST13) sulfate chondroitin to form chondroitin-4-sulfate Structure: - composed of alternating sulfated N-acetyl-galactosamine & glucuronate residues (1,3 beta linkage) Pharmacology: - used for treatment of osteoarthritis - often combined with glucosamine - Refs [5,6] suggest combined with glucosamine no better than glucosamine alone - Ref [7,8] suggests chrondroitin useless - no benefit of glucosamine or chondroitin for attenuating joint space narrowing [9] - may delay progression of knee osteoarthritis; however, pain benefits not clear [10] - neither glucosamine, chondroitin or combination of the two beneficial in osteoarthritis of the knee [12] - pharmaceutical-grade chondroitin sulfate 800 mg/day as effective as celecoxib for osteoarthritis of the knee [13] - may benefit hand osteoarthritis [9]

Interactions

drug interactions

Related

NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

Specific

chondroitin sulfate proteoglycan

General

glycosaminoglycan

Properties

Database Correlations

PUBCHEM cid=24766 Kegg map/map00532

References

  1. Journal Watch 20(4):31, 2000; 20(8):64, 2000
  2. Leeb BFet al A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis. J. Rheumatol. 27:205, 2000 PMID: 10648040
  3. McAlindon TE et al Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283:1469, 2000 PMID: 10732937
  4. Towheed TE & Anastassiades TP Glucosamine and chondroitin for treating symptoms of osteoarthritis: evidence is widely touted but incomplete. JAMA 283:1483, 2000 PMID: 10732941
  5. Prescriber's Letter 8(2):7, Feb, 2001
  6. Prescriber's Letter 9(7):37 2002
  7. Reichenbach S, Sterchi R, Scherer M, Trelle S, Burgi E, Burgi U, Dieppe PA, Juni P. Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Ann Intern Med. 2007 Apr 17;146(8):580-90. PMID: 17438317 - Felson DT. Chondroitin for pain in osteoarthritis. Ann Intern Med. 2007 Apr 17;146(8):611-2. PMID: 17438322
  8. Prescriber's Letter 14(6): 2007 Is Chondroitin Effective for Osteoarthritis? Detail-Document#: 230612 (subscription needed) http://www.prescribersletter.com
  9. Sawitzke AD et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the Glucosamine/chondroitin Arthritis Intervention Trial. Arthritis Rheum 2008 Oct; 58:3183. PMID: 18821708
  10. Kahan A et al. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: The Study on Osteoarthritis Progression Prevention, a two-year, randomized, double-blind, placebo- controlled trial. Arthritis Rheum 2009 Feb; 60:524. PMID: 19180484
  11. Gabay C et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: A randomized, double-blind, placebo- controlled clinical trial at a single center. Arthritis Rheum 2011 Nov; 63:3383 PMID: 21898340
  12. Fransen M et al. Glucosamine and chondroitin for knee osteoarthritis: A double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis 2015 May; 74:851 PMID: 24395557 http://ard.bmj.com/content/74/5/851
  13. Reginster JY, Dudler J, Blicharski T, Pavelka K Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Annals of Rheumatic Diseases. May 2017 PMID: 28533290 Free full text http://ard.bmj.com/content/early/2017/04/29/annrheumdis-2016-210860

Component-of

calcium carbonate/cholecalferol/chondroitin sulfate/glucosamine capsaicin/chondroitin sulfate/glucosamine/lidocaine chondroitin sulfate/c kit protein/hyaluronate chondroitin sulfate/glucosamine chondroitin sulfate/glucosamine 2 sulfate chondroitin sulfate/glucosamine 2 sulfate/ibuprofen chondroitin sulfate/glucosamine 2 sulfate/methylsulfonylmethane chondroitin sulfate/glucosamine/methylsulfonylmethane chondroitin sulfate/hyaluronate chondroitin sulfate/hyaluronate based injectable gel heparinoid