charged multivesicular body protein 4C; chromatin-modifying protein 4c; CHMP4c; SNF7 homolog associated with Alix 3; SNF7-3; hSnf7-3; vacuolar protein sorting-associated protein 32-3; Vps32-3; hVps32-3 (CHMP4C, SHAX3)

Function: 1) component of ESCRT3 in the multivesicular body pathway 2) in the ESCRT3 complex, it interacts directly with CHMP4A, CHMP4B, CHMP6 3) self-associates 4) interacts with PDCD6IP of ESCRT1 complex 5) interacts with CHMP2A 6) interacts with VPS4A Structure: - the acidic C-terminus & the basic N-termminus are thought to render the protein in a closed, soluble & inactive conformation through an autoinhibitory intramolecular interaction - the open & active conformation, which enables membrane binding & oligomerization, is facilitated by interaction with other ESCRT components (putative) - belongs to the SNF7 family Compartment: cytoplasm, late endosome membrane Expression: expressed in heart, spleen, kidney Pathology: - the HIV-1 virus takes advantage of ESCRT3 for budding & exocytosis of viral proteins, via the association of CHMP4 proteins with PDCD6IP, a protein directly recruited by HIV-1 p6 protein that functions at sites of viral Gag assembly & budding - overexpression strongly inhibits HIV-1 release

Properties

SIZE: entity length = 233 aa MW = 26 kD COMPARTMENT: cytoplasm MOTIF: domain {1-153} coiled coil {125-183} domain {154-233}

Database Correlations

OMIM 610899 UniProt Q96CF2 Pfam PF03357 Entrez Gene 92421 Kegg hsa:92421

References

UniProt :accession Q96CF2